Description

2-Bromo-4-Fluoropyridine-3-Carbaldehyde is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents adjacent to an aldehyde group, makes it an essential precursor for constructing complex heterocyclic systems. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluoropyridine core contributes to biological activity and metabolic stability.
• Material Science Precursor: Serves as a starting material for the creation of functionalized ligands, organic semiconductors, and liquid crystals.
• Cross-Coupling Reactions: The bromine substituent is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to introduce complex aryl and heteroaryl groups.
• Aldehyde Functionalization: The formyl group allows for further derivatization via condensation, reduction, or oxidation to create a wide array of functional molecules.

Basic Information

Product Name	2-Bromo-4-Fluoropyridine-3-Carbaldehyde
CAS No.	1289015-40-2
Molecular Formula	C6H3BrFNO
Molecular Weight	204.00 g/mol
Synonyms	3-Bromo-6-fluoropyridine-4-carbaldehyde; 4-Fluoro-2-bromopyridine-3-carboxaldehyde; 2-Bromo-4-fluoropyridine-3-carboxaldehyde; 3-Formyl-2-bromo-4-fluoropyridine; 6-Fluoro-3-bromopyridine-4-carbaldehyde; 2-Bromo-4-fluoro-3-pyridinecarbaldehyde; 1289015-40-2
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-Fluoropyridine-3-Carbaldehyde is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile as determined by HPLC, NMR, and other relevant analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.