Description

4-(5-Fluoropyridin-2-Yl)Morpholine is a high-value fluorinated heterocyclic building block, specifically a morpholine-substituted pyridine derivative, essential for modern pharmaceutical and agrochemical research. Its core value lies in its unique molecular architecture, which combines a fluorine atom and a morpholine ring on a pyridine scaffold, enabling precise modulation of biological activity, lipophilicity, and metabolic stability in target molecules. This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the design and production of advanced pesticides and herbicides, where the fluorine atom enhances bioactivity and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating molecular probes and tool compounds to study enzyme function and protein-ligand interactions.
• Material Science Research: Investigated as a precursor for specialty polymers and liquid crystals due to its rigid, heteroaromatic structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in synthetic organic chemistry and heterocyclic chemistry.

Basic Information

Product Name	4-(5-Fluoropyridin-2-Yl)Morpholine
CAS No.	1287217-51-9
Molecular Formula	C9H11FN2O
Molecular Weight	182.20 g/mol
Synonyms	2-(5-Fluoropyridin-2-yl)morpholine; 4-(5-Fluoropyridin-2-yl)morpholine; Morpholine, 4-(5-fluoro-2-pyridinyl)-; 5-Fluoro-2-morpholinopyridine; 2-Morpholino-5-fluoropyridine; 5-Fluoro-2-(morpholin-4-yl)pyridine; 1287217-51-9
EINECS	Contact for details

Quality Control

Our 4-(5-Fluoropyridin-2-Yl)Morpholine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.