Description

2-Methyl-D-Proline Methyl Ester Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and chiral catalysts. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications requiring precise stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Used as a precursor or auxiliary in asymmetric synthesis to induce chirality and create enantiomerically pure compounds.
• Peptidomimetics Research: Serves as a constrained proline analog in the design and synthesis of peptidomimetics for drug discovery programs.
• Agrochemical Development: Employed in the synthesis of chiral active ingredients for advanced crop protection agents.
• Catalyst Ligand Preparation: A potential building block for the synthesis of novel chiral ligands used in homogeneous catalysis.
• Academic & Process R&D: Utilized in academic research and process development for method optimization and scale-up studies.

Basic Information

Product Name	2-Methyl-D-Proline Methyl Ester Hydrochloride
CAS No.	1286768-32-8
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	Methyl (2R)-2-methylpyrrolidine-2-carboxylate hydrochloride; D-2-Methylproline methyl ester HCl; (R)-2-Methylpyrrolidine-2-carboxylic acid methyl ester hydrochloride; Methyl (R)-2-methylpyrrolidine-2-carboxylate hydrochloride; (2R)-2-Methyl-1-pyrrolidinecarboxylic acid methyl ester hydrochloride; 2-Methyl-D-proline methyl ester HCl salt; Proline, 2-methyl-, methyl ester, hydrochloride, D-
EINECS	Contact for details

Quality Control

Our 2-Methyl-D-Proline Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.