Description

tert-Butyl 1-Nicotinoylpiperidin-4-Ylcarbamate is a high-purity pharmaceutical intermediate and building block with the CAS number 1286273-90-2. This compound is of significant value in medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Protease Inhibitor Development: Serves as a precursor in the creation of inhibitors for various enzymatic pathways.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological mechanisms and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 1-Nicotinoylpiperidin-4-Ylcarbamate
CAS No.	1286273-90-2
Molecular Formula	C16H23N3O3
Molecular Weight	305.37 g/mol
Synonyms	1-Nicotinoylpiperidine-4-carboxylic acid tert-butylamide; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(3-pyridinylcarbonyl)piperidine; tert-Butyl N-(1-nicotinoylpiperidin-4-yl)carbamate; 1-(Pyridine-3-carbonyl)piperidine-4-carboxylic acid tert-butylamide; 4-(tert-Butoxycarbonylamino)-1-(nicotinoyl)piperidine; BOC-Nicotinoyl-piperidine-4-yl-amine; tert-Butyl 4-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Nicotinoylpiperidin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with complete traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.