Description

n-[(1R*,4R*)-4-Aminocyclohexyl]Isonicotinamide Dihydrochloride is a high-purity, pharmaceutically relevant chemical intermediate characterized by its specific stereochemistry and dihydrochloride salt form. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study biological processes and enzyme functions.
• Custom Synthesis: Employed in contract research and manufacturing (CRO/CMO) for the production of specialized, non-commercial compounds.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-[(1R*,4R*)-4-Aminocyclohexyl]Isonicotinamide Dihydrochloride
CAS No.	1286273-64-0
Molecular Formula	C13H20N4O · 2HCl
Molecular Weight	329.25 g/mol (free base: 248.33 g/mol)
Synonyms	4-Aminocyclohexyl isonicotinamide dihydrochloride; (1R*,4R*)-4-Aminocyclohexyl isonicotinamide dihydrochloride; trans-4-Aminocyclohexyl isonicotinamide dihydrochloride; Isonicotinamide, N-[(1R*,4R*)-4-aminocyclohexyl]-, dihydrochloride; UNII-Contact for details; PC-Contact for details; 1286273-64-0; 4-Pyridinecarboxamide, N-[(1R*,4R*)-4-aminocyclohexyl]-, dihydrochloride
EINECS	Contact for details

Quality Control

Our n-[(1R*,4R*)-4-Aminocyclohexyl]Isonicotinamide Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation by spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.