Description

n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Isobutyramide is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core and a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting kinase inhibition.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic ester moiety facilitates the formation of carbon-carbon bonds under mild conditions, essential for constructing biaryl structures in drug molecules.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Agrochemical Development: Employed in the research and synthesis of novel crop protection agents with specific activity.
• Material Science Research: Investigated for the creation of organic electronic materials and metal-organic frameworks (MOFs).

Basic Information

Item	Information
Product Name	n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Isobutyramide
CAS No.	1286230-84-9
Molecular Formula	C16H25BN2O3
Molecular Weight	304.20 g/mol
Synonyms	2-Isobutyramido-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2-methylpropanamido)pyridine; N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]isobutyramide; Isobutyramide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; 1286230-84-9; 2-Pyridinecarboxamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-methylpropyl)-
EINECS	Contact for details

Quality Control

Our n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl)Isobutyramide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.