Description

(R)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is a high-purity chiral intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for medicinal chemists and process development scientists in pharmaceutical companies and contract research organizations (CROs) who require enantiomerically pure intermediates for preclinical and clinical studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for neurological and psychiatric targets.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of enantiomerically pure APIs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Asymmetric Synthesis: Employed in the development of catalytic asymmetric reactions due to its defined stereochemistry.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in regulatory filings.
• Biochemical Research: Potential use as a tool compound for probing enzyme mechanisms or receptor binding studies.

Basic Information

Item	Details
Product Name	(R)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride
CAS No.	1286209-00-4
Molecular Formula	C9H12N3O3·HCl
Molecular Weight	261.67 g/mol
Synonyms	(R)-5-Nitro-2-((3-pyrrolidinyl)oxy)pyridine hydrochloride; (R)-2-((Pyrrolidin-3-yl)oxy)-5-nitropyridine hydrochloride; (R)-5-Nitro-2-(3-pyrrolidinyloxy)pyridine HCl; (R)-5-Nitro-2-(pyrrolidin-3-yloxy)pyridine hydrochloride; (3R)-5-Nitro-2-(pyrrolidin-3-yloxy)pyridine hydrochloride; Pyridine, 5-nitro-2-[(3R)-3-pyrrolidinyl]oxy-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our (R)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity, chiral HPLC for enantiomeric excess (ee), and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and regulatory needs with material suitable for use under cGMP guidelines for early-phase clinical trials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.