Description

(S)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is a high-purity chiral intermediate and building block of significant importance in modern pharmaceutical research and development. Its defined stereochemistry and functionalized pyridine-pyrrolidine scaffold make it a valuable precursor for synthesizing targeted bioactive molecules. This compound is primarily sought after by pharmaceutical companies and advanced research institutions engaged in the discovery of new therapeutic agents, particularly within the domains of central nervous system (CNS) and oncology drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent, selective drug candidates, especially for neurological and oncological targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in the research and process development of novel APIs requiring a specific (S)-configured pyrrolidinyloxy moiety.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis to explore new chemical entities for biological screening.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to construct complex molecular architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical clients with custom synthesis and scale-up projects.
• Reference Standard: Utilized as an analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	(S)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride
CAS No.	1286208-57-8
Molecular Formula	C9H12N3O3 • HCl
Molecular Weight	261.67 g/mol (Free base: 225.21 g/mol)
Synonyms	(S)-5-Nitro-2-((3-pyrrolidinyl)oxy)pyridine hydrochloride; (S)-2-((Pyrrolidin-3-yl)oxy)-5-nitropyridine hydrochloride; (S)-5-Nitro-2-(3-pyrrolidinyloxy)pyridine HCl; (S)-5-Nitro-2-(pyrrolidin-3-yloxy)pyridine monohydrochloride; (S)-5-Nitro-2-(3-pyrrolidinoxy)pyridine hydrochloride; (S)-5-Nitro-2-(pyrrolidin-3-yloxy)pyridine HCl salt; (S)-5-Nitro-2-(3-pyrrolidinyloxy)pyridine hydrochloride; (S)-5-Nitro-2-(pyrrolidin-3-yloxy)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-5-Nitro-2-(Pyrrolidin-3-Yloxy)Pyridine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to ICH guidelines for impurity identification and control, and our analytical methods are validated to ensure accurate and reliable results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.