Description

(R)-n-(Piperidin-3-Yl)Nicotinamide Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for research and development in medicinal chemistry, particularly for creating targeted small molecule therapeutics. It is primarily needed by pharmaceutical companies, biotechnology research firms, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of novel drug candidates targeting neurological disorders, oncology, and metabolic diseases.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology Probe Development: Serves as a starting material for creating labeled or tagged compounds used to study biological pathways and protein-ligand interactions.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final synthetic route for the production of investigational or commercial pharmaceutical compounds.
• Contract Manufacturing: Supplied to CDMOs for use in custom synthesis and scale-up projects under current Good Manufacturing Practice (cGMP) guidelines.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	(R)-n-(Piperidin-3-Yl)Nicotinamide Dihydrochloride
CAS No.	1286208-52-3
Molecular Formula	C11H16N3O • 2HCl
Molecular Weight	291.19 g/mol (for free base: 206.27 g/mol)
Synonyms	(R)-N-(Piperidin-3-yl)nicotinamide dihydrochloride; (R)-3-(Nicotinamido)piperidine dihydrochloride; (R)-N-(3-Piperidyl)pyridine-3-carboxamide dihydrochloride; (R)-Nicotinoyl-3-aminopiperidine dihydrochloride; (R)-3-Aminopiperidine nicotinamide dihydrochloride; (R)-3-Piperidinamine, N-(3-pyridinylcarbonyl)-, dihydrochloride; (R)-PNA Dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-n-(Piperidin-3-Yl)Nicotinamide Dihydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support development with analytical method development and can supply material under cGMP standards for advanced clinical trial stages, with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment after opening to prevent degradation. Long-term storage at 2-8°C is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.