Description

(R)-(3-Aminopyrrolidin-1-Yl)(Pyridin-2-Yl)Methanone Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial and research interest. Its value lies in its defined stereochemistry and functional groups, which are critical for the synthesis of targeted bioactive molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Serves as a starting material or advanced intermediate for the pilot and commercial-scale synthesis of candidate drugs.
• Bioconjugation & Probe Development: The aminopyrrolidine moiety can be utilized for conjugation chemistry in the development of diagnostic probes or targeted drug delivery systems.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.

Basic Information

Item	Details
Product Name	(R)-(3-Aminopyrrolidin-1-Yl)(Pyridin-2-Yl)Methanone Dihydrochloride
CAS No.	1286208-51-2
Molecular Formula	C10H14N3O • 2HCl
Molecular Weight	279.16 g/mol (Free base: 192.24 g/mol)
Synonyms	(R)-N-(2-Pyridinyl)-3-amino-1-pyrrolidinecarboxamide dihydrochloride; (R)-3-Amino-1-(pyridin-2-ylcarbonyl)pyrrolidine dihydrochloride; (R)-1-(Pyridine-2-carbonyl)pyrrolidin-3-amine dihydrochloride; (R)-(3-Aminopyrrolidin-1-yl)(2-pyridyl)methanone dihydrochloride; UNII-9K3J4Q8B6P; 9K3J4Q8B6P; (R)-ANPPM dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of (R)-(3-Aminopyrrolidin-1-Yl)(Pyridin-2-Yl)Methanone Dihydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research specifications, with comprehensive testing via HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.