Description

(R)-tert-Butyl 1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and other therapeutic areas. Pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) require this material for its structural utility in creating complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used in the construction of complex molecules where the (R)-configured pyrrolidine scaffold is essential for biological activity.
• Medicinal Chemistry Research: Serves as a versatile precursor in drug discovery programs for hit-to-lead and lead optimization phases.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Ligand and Catalyst Preparation: Can be utilized in the development of chiral ligands or organocatalysts for asymmetric transformations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	(R)-tert-Butyl 1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Ylcarbamate
CAS No.	1286207-55-3
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	Carbamic acid, N-[(3R)-1-(4-pyridinylmethyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester; (R)-tert-Butyl 1-(4-pyridylmethyl)pyrrolidin-3-ylcarbamate; (R)-1-(Pyridin-4-ylmethyl)pyrrolidin-3-yl tert-butylcarbamate; tert-Butyl ((R)-1-(pyridin-4-ylmethyl)pyrrolidin-3-yl)carbamate; (R)-N-Boc-1-(4-Picolyl)-3-aminopyrrolidine; (R)-3-((tert-Butoxycarbonyl)amino)-1-(pyridin-4-ylmethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-(Pyridin-4-Ylmethyl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.