Description

6-((2R,6S)-2,6-Dimethylmorpholino)Pyridin-3-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a stereochemically defined morpholino-pyridine scaffold essential for developing targeted small-molecule therapeutics. This advanced intermediate is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and commercial synthesis of novel drug candidates.
• Kinase Inhibitor Development: Core structural component for designing potent and selective kinase inhibitors.
• CNS-Active Compound Synthesis: Building block for molecules targeting neurological disorders.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for GMP manufacturing.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies due to its defined stereochemistry.
• Reference Standard: Serves as an analytical standard for quality control and regulatory filings.

Basic Information

Item	Details
Product Name	6-((2R,6S)-2,6-Dimethylmorpholino)Pyridin-3-Amine Hydrochloride
CAS No.	1282295-12-8
Molecular Formula	C11H18ClN3O
Molecular Weight	243.73 g/mol
Synonyms	(2R,6S)-2,6-Dimethyl-4-(5-amino-2-pyridinyl)morpholine hydrochloride; 6-[(2R,6S)-2,6-Dimethylmorpholin-4-yl]pyridin-3-amine hydrochloride; 5-Amino-6-((2R,6S)-2,6-dimethylmorpholino)pyridine hydrochloride; (R,S)-6-(2,6-Dimethylmorpholino)pyridin-3-amine HCl; UNII-Contact for details; 1282295-12-8 (CAS); 6-(2,6-Dimethylmorpholino)-3-pyridinamine hydrochloride (mixed isomers)
EINECS	Contact for details

Quality Control

Every batch of 6-((2R,6S)-2,6-Dimethylmorpholino)Pyridin-3-Amine Hydrochloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and isomeric purity compliant with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.