Description

(4Ar,6S,7As)-tert-Butyl 6-Aminohexahydro-1H-Cyclopenta[C]Pyridine-2(3H)-Carboxylate is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) requiring specific chiral configurations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in the fields of neurology and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly those targeting G-protein-coupled receptors (GPCRs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing novel nitrogen-containing heterocyclic frameworks with defined stereochemistry.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Medicinal Chemistry: Enables the exploration of structure-activity relationships (SAR) by providing a rigid, functionalized bicyclic scaffold for analog development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.

Basic Information

Product Name	(4Ar,6S,7As)-tert-Butyl 6-Aminohexahydro-1H-Cyclopenta[C]Pyridine-2(3H)-Carboxylate
CAS No.	1280666-49-0
Molecular Formula	C14H26N2O2
Molecular Weight	254.37 g/mol
Synonyms	tert-Butyl (4aR,6S,7aS)-6-aminohexahydro-1H-cyclopenta[c]pyridine-2(3H)-carboxylate; (4aR,6S,7aS)-2-(tert-Butoxycarbonyl)-2,3,4,4a,5,6,7,7a-octahydro-1H-cyclopenta[c]pyridin-6-amine; 6-Aminohexahydro-1H-cyclopenta[c]pyridine-2(3H)-carboxylic acid tert-butyl ester; BOC-protected amino cyclopentapyridine; (4aR,6S,7aS)-6-Amino-1,2,3,4,4a,5,6,7a-octahydrocyclopenta[c]pyridine-2-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (4Ar,6S,7As)-tert-Butyl 6-Aminohexahydro-1H-Cyclopenta[C]Pyridine-2(3H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.