Description

(S)-(((1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yloxy)Methyl)Phosphoryl)Bis(Oxy)Bis(Methylene) Isopropyl Dicarbonate is a high-purity, advanced pharmaceutical intermediate and prodrug building block. This compound is of significant interest for its role in the synthesis of novel antiviral and anticancer nucleotide analogs, offering a critical pathway for targeted drug delivery and enhanced therapeutic efficacy. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antiviral therapies and oncology treatments.

Application

• Antiviral Prodrug Synthesis: A key intermediate for the development of prodrugs targeting viral polymerases, particularly for hepatitis B (HBV) and hepatitis C (HCV) therapies.
• Oncology Research: Used in the synthesis of nucleotide analogs designed to inhibit cancer cell proliferation and DNA replication.
• Pharmaceutical Intermediates: Serves as a sophisticated building block for constructing active pharmaceutical ingredients (APIs) with improved bioavailability and metabolic stability.
• Biochemical Research: Employed in academic and industrial R&D for studying nucleotide metabolism and enzyme inhibition mechanisms.
• Precision Medicine Development: Facilitates the creation of targeted therapeutic agents with specific chiral configurations for enhanced potency and reduced side effects.

Basic Information

Product Name	(S)-(((1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yloxy)Methyl)Phosphoryl)Bis(Oxy)Bis(Methylene) Isopropyl Dicarbonate
CAS No.	1280130-08-6
Molecular Formula	C19H28N5O10P
Molecular Weight	517.43 g/mol
Synonyms	Isopropyl (((((S)-1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(hydroxy)phosphoryl) bis(methylene) dicarbonate; Tenofovir Isopropyloxycarbonyloxymethyl Ester Prodrug Intermediate; (S)-HPMPA Prodrug Derivative; (S)-9-[2-[[Bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine; GS-7340 Related Compound; PMPA Prodrug Ester; Adefovir Dipivoxil Analog; Nucleotide Phosphonate Prodrug
EINECS	Contact for details

Quality Control

Our (S)-(((1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yloxy)Methyl)Phosphoryl)Bis(Oxy)Bis(Methylene) Isopropyl Dicarbonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling via HPLC, to ensure compliance with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and residual solvents are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.