Description

1-(2-Bromopyridin-4-Yl)Cyclopropanecarbonitrile is a high-value brominated pyridine derivative featuring a cyclopropane-carbonitrile moiety, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique bifunctional structure makes it an essential building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for bioactivity.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands in catalysis and materials science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Functional Material Development: Building block for organic electronic materials, such as those used in OLEDs or sensors, due to its conjugated system and halogen handle.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.

Basic Information

Item	Details
Product Name	1-(2-Bromopyridin-4-Yl)Cyclopropanecarbonitrile
CAS No.	1279815-46-1
Molecular Formula	C9H7BrN2
Molecular Weight	223.07 g/mol
Synonyms	1-(2-Bromo-4-pyridinyl)cyclopropanecarbonitrile; 1-(2-Bromopyridin-4-yl)cyclopropanecarbonitrile; 1-(2-Bromopyridin-4-Yl)Cyclopropanecarbonitrile; 4-(1-Cyanocyclopropyl)-2-bromopyridine; 2-Bromo-4-(1-cyanocyclopropyl)pyridine; Cyclopropanecarbonitrile, 1-(2-bromo-4-pyridinyl)-; 1279815-46-1
EINECS	Contact for details

Quality Control

Our 1-(2-Bromopyridin-4-Yl)Cyclopropanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.