Description

(2S,4S)-1-Cbz-2-Hydroxymethyl-4-Aminopyrrolidine Hydrochloride is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced pharmaceutical synthesis. This compound is valued for its defined stereochemistry and functional groups, which enable the construction of complex molecular architectures with high enantiomeric purity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for therapeutic areas requiring sophisticated chiral scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for protease inhibitors and other biologically active molecules.
• Peptidomimetics Synthesis: Used to construct constrained peptide analogs and peptidomimetics due to its pyrrolidine backbone and amine functionality.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other catalytic processes.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Process Chemistry & Scale-Up: Suitable for use in process development and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines for pharmaceutical production.

Basic Information

Product Name	(2S,4S)-1-Cbz-2-Hydroxymethyl-4-Aminopyrrolidine Hydrochloride
CAS No.	1279038-54-8
Molecular Formula	C14H21N2O3•HCl
Molecular Weight	300.79 g/mol (Free base: 265.33 g/mol)
Synonyms	1-[(Benzyloxy)carbonyl]-(2S,4S)-2-(hydroxymethyl)-4-aminopyrrolidine hydrochloride; (2S,4S)-1-(Carbobenzyloxy)-2-(hydroxymethyl)-4-aminopyrrolidine hydrochloride; (2S,4S)-1-Cbz-4-Amino-2-(hydroxymethyl)pyrrolidine HCl; (2S,4S)-4-Amino-1-Cbz-2-(hydroxymethyl)pyrrolidine hydrochloride; Cbz-(2S,4S)-AHP-HCl; (S,S)-1-Cbz-2-Hydroxymethyl-4-Aminopyrrolidine HCl; N-Carbobenzyloxy-(2S,4S)-2-hydroxymethyl-4-aminopyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-Cbz-2-Hydroxymethyl-4-Aminopyrrolidine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to relevant quality guidelines and specifications can be aligned with customer requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (2S,4S)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.