Description

tert-Butyl 4-(5-formyl-3-methylpyridin-2-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique piperazine-pyridine hybrid scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive aldehyde and protected amine functionalities.
• Custom Synthesis Building Block: Employed in the construction of heterocyclic compounds and complex molecular architectures for contract research organizations (CROs) and CDMOs.
• API Development: Integral in the development and scale-up processes for new chemical entities (NCEs) in preclinical and early-phase clinical trials.
• Chemical Biology Probes: Serves as a starting material for creating labeled compounds or probes used in biochemical and cellular assays.

Basic Information

Product Name	tert-Butyl 4-(5-Formyl-3-Methylpyridin-2-yl)piperazine-1-carboxylate
CAS No.	1279027-72-3
Molecular Formula	C16H23N3O3
Molecular Weight	305.37 g/mol
Synonyms	Boc-4-(5-Formyl-3-methyl-2-pyridyl)piperazine; 1-Boc-4-(5-Formyl-3-methyl-2-pyridinyl)piperazine; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-formyl-3-methylpyridine; tert-Butyl 4-(5-formyl-3-methyl-2-pyridinyl)-1-piperazinecarboxylate; 1279027-72-3; 1-Piperazinecarboxylic acid, 4-(5-formyl-3-methyl-2-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-formyl-3-methylpyridin-2-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere to prevent oxidation. Keep away from strong oxidizing agents and moisture. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.