Description

(1-Methyl-2-Oxo-Propyl)-Carbamic Acid tert-Butyl Ester is a protected amino acid derivative, specifically a tert-butyloxycarbonyl (Boc) protected α-keto amide. This compound serves as a versatile and critical building block in organic synthesis, particularly in the development of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for peptide synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting protease enzymes.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid derivative to construct specific peptide sequences.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: Serves as a building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients.
• Bioconjugation: Potential use in the preparation of peptide-based conjugates for diagnostic or targeted drug delivery systems.
• Chemical Biology Probes: Useful for creating enzyme inhibitors or activity-based probes to study biological pathways.

Basic Information

Item	Details
Product Name	(1-Methyl-2-Oxo-Propyl)-Carbamic Acid tert-Butyl Ester
CAS No.	1277097-51-4
Molecular Formula	C9H17NO3
Molecular Weight	187.24 g/mol
Synonyms	Boc-α-keto-valine; tert-Butyl (1-methyl-2-oxopropyl)carbamate; 2-Oxo-3-methylbutanoic acid N-Boc derivative; N-(tert-Butoxycarbonyl)-2-oxo-3-methylbutanamide; 3-Methyl-2-oxobutanoyl tert-butyl carbamate; Boc-protected 2-oxovaline; α-Keto-N-Boc-valine
EINECS	Contact for details

Quality Control

Our (1-Methyl-2-Oxo-Propyl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.