Description

2-Chloro-3-Methylamine-5-Trifluoromethylpyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a distinct trifluoromethylpyridine core structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Chemical Research & Development: Serves as a versatile precursor for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and molecular recognition applications.
• Custom Synthesis Projects: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis for client-specific molecules.

Basic Information

Product Name	2-Chloro-3-Methylamine-5-Trifluoromethylpyridine Hydrochloride
CAS No.	1276056-69-9
Molecular Formula	C8H9Cl2F3N2
Molecular Weight	261.07 g/mol
Synonyms	2-Chloro-3-(methylamino)-5-(trifluoromethyl)pyridine hydrochloride; 3-Amino-2-chloro-5-trifluoromethylpyridine N-methyl hydrochloride; 2-Chloro-N-methyl-5-(trifluoromethyl)pyridin-3-amine hydrochloride; 5-Trifluoromethyl-2-chloro-3-methylaminopyridine HCl; 1276056-69-9; 2-Chloro-3-methylamino-5-trifluoromethylpyridine HCl salt
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Methylamine-5-Trifluoromethylpyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.