Description

1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylazepane is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonamide-linked heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel small molecule therapeutics. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery and development, particularly for programs targeting central nervous system (CNS) disorders, inflammation, and oncology.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those containing functionalized azepane and pyridine motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead and lead optimization campaigns.
• Protease Inhibitor Development: Serves as a scaffold or building block for designing inhibitors of specific enzymes, such as kinases or proteases.
• Chemical Biology Probes: Utilized in the development of chemical probes to study biological pathways and protein function.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for fundamental research in organic synthesis and new reaction methodology development.

Basic Information

Product Name	1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylazepane
CAS No.	1275357-18-0
Molecular Formula	C12H17BrN2O2S
Molecular Weight	333.25 g/mol
Synonyms	4-Methyl-1-[(5-bromopyridin-3-yl)sulfonyl]azepane; 1-[(5-Bromo-3-pyridinyl)sulfonyl]-4-methylazepane; 4-Methyl-1-(5-bromopyridine-3-sulfonyl)azepane; Azepane, 1-[(5-bromo-3-pyridinyl)sulfonyl]-4-methyl-; 1275357-18-0; 5-Bromo-3-[(4-methylazepan-1-yl)sulfonyl]pyridine
EINECS	Contact for details

Quality Control

Our 1-(5-Bromopyridin-3-Ylsulfonyl)-4-Methylazepane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.