Description

3-(2-(Chloromethyl)Pyrrolidin-1-Ylsulfonyl)-5-Fluoropyridine CAS NO 1273683-57-0 is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidine-sulfonyl-pyridine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical and biotechnology companies for the development of new therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Development: Serves as a core structural motif in the design of enzyme inhibitors, leveraging the sulfonamide and fluoropyridine functional groups.
• Chemical Biology Probes: Employed in the creation of tool compounds for target validation and mechanistic studies in biological systems.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.
• Agrochemical Research: Potential application in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	3-(2-(Chloromethyl)Pyrrolidin-1-Ylsulfonyl)-5-Fluoropyridine
CAS No.	1273683-57-0
Molecular Formula	C10H12ClFN2O2S
Molecular Weight	278.73 g/mol
Synonyms	5-Fluoro-3-[(2-chloromethyl-1-pyrrolidinyl)sulfonyl]pyridine; 3-[(2-Chloromethylpyrrolidin-1-yl)sulfonyl]-5-fluoropyridine; 1-(5-Fluoropyridin-3-ylsulfonyl)-2-(chloromethyl)pyrrolidine; 5-Fluoro-3-(2-chloromethyl-pyrrolidine-1-sulfonyl)-pyridine; 3-(2-Chloromethyl-1-pyrrolidinesulfonyl)-5-fluoropyridine
EINECS	Contact for details

Quality Control

Our 3-(2-(Chloromethyl)Pyrrolidin-1-Ylsulfonyl)-5-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.