Description

4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazoline scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel drug candidates. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, drug-like spirocyclic structure.
• Protease Inhibitor Development: The quinazoline core is a privileged structure in the design of enzyme inhibitors.
• Kinase Inhibitor Scaffold: Serves as a central scaffold for developing potential kinase inhibitors for oncology applications.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological targets and mechanisms of action.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke APIs and advanced intermediates under cGMP conditions.

Basic Information

Product Name	4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-5-Carboxylic Acid
CAS No.	1272756-14-5
Molecular Formula	C14H14N2O3
Molecular Weight	258.27 g/mol
Synonyms	5-Carboxy-4-oxospiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclopentane]; Spiro[cyclopentane-1,2'-[1,2,3,4]tetrahydroquinazoline]-4-one-5-carboxylic acid; 1272756-14-5; 4-Oxo-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclopentane]-5-carboxylic acid; Tetrahydrospiro[cyclopentane-1,2'-quinazoline]-4(3H)-one-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.