Description

6-Bromospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazolinone scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential for enhanced biological activity and selectivity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, CNS disorders, and other therapeutic areas requiring complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic and brominated functional groups.
• Chemical Biology Probes: Employed in the development of chemical probes to study protein function and biological mechanisms.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) in drug discovery.
• Process Chemistry Development: Used in route scouting and scale-up studies for the production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and research institutes for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	6-Bromospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One
CAS No.	1272756-13-4
Molecular Formula	C₁₂H₁₁BrN₂O
Molecular Weight	279.14 g/mol
Synonyms	6-Bromo-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclobutan]-4-one; 6-Bromospiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]-4(3H)-one; 6-Bromo-1,2,3,4-tetrahydro-4-oxospiro[quinazoline-2,1'-cyclobutane]; 6-Bromo-3,4-dihydro-1H-spiro[quinazoline-2,1'-cyclobutan]-4-one; Spiro[cyclobutane-1,2'-[1,2,3,4]tetrahydroquinazolin]-4'-one, 6'-bromo-; 1272756-13-4; 6-Bromo-spiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]-4-one
EINECS	Contact for details

Quality Control

Our 6-Bromospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.