Description

4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carbonitrile is a high-value, spirocyclic organic building block and advanced pharmaceutical intermediate. Its unique fused heterocyclic structure makes it a critical precursor for the synthesis of novel bioactive compounds, particularly in medicinal chemistry and drug discovery. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors developing new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new pharmacophores and optimize lead compounds.
• Agrochemical Development: Serves as a precursor for creating new active ingredients in crop protection products, such as herbicides and insecticides.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value specialty chemicals and functional materials.
• Academic & R&D Laboratories: Utilized in universities and contract research organizations (CROs) for exploratory synthetic chemistry and methodological development.

Basic Information

Product Name	4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carbonitrile
CAS No.	1272756-09-8
Molecular Formula	C₁₃H₁₁N₃O
Molecular Weight	225.25 g/mol
Synonyms	5-Cyano-4-oxospiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]; 4-Oxo-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclobutane]-5-carbonitrile; Spiro[cyclobutane-1,2'-[1,2,3,4]tetrahydroquinazoline]-4-one-5'-carbonitrile; 1272756-09-8; Quinazoline-5-carbonitrile, 1,2,3,4-tetrahydro-4-oxospiro[2,1'-cyclobutane]-; Tetrahydroquinazoline spirocyclobutane carbonitrile derivative.
EINECS	Contact for details

Quality Control

Our 4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.