Description

5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-4-One is a high-value, advanced pharmaceutical intermediate characterized by its unique spirocyclic quinazolinone structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel drug candidates targeting complex biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and specialty chemical manufacturers seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially for oncology and central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic and fluorinated motifs.
• Agrochemical Development: Serves as a precursor in the research of new-generation pesticides and herbicides with enhanced activity.
• Chemical Biology Probes: Employed in the development of chemical probes for studying enzyme function and protein-ligand interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and heterocyclic compound research.

Basic Information

Product Name	5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-4-One
CAS No.	1272756-06-5
Molecular Formula	C₁₃H₁₃FN₂O
Molecular Weight	232.26 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclopentane]-4-one; 5-Fluoro-1,2,3,4-tetrahydrospiro[cyclopentane-1,2'-quinazolin]-4'(3'H)-one; 5-Fluorospiro[cyclopentane-1,2'-quinazolin]-4'(3'H)-one; 5-Fluoro-1,2,3,4-tetrahydro-2,1-ethanoquinazolin-4-one; Spiro[cyclopentane-1,2'-quinazolin]-4'(3'H)-one, 5'-fluoro-1',2',3',4'-tetrahydro-; 1272756-06-5; 5-Fluoro-THQ-Cyclopentane-4-one
EINECS	Contact for details

Quality Control

Our 5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclopentane]-4-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.