Description

4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic quinazoline structure. This compound is valued for its role as a critical building block in the synthesis of novel, small-molecule drug candidates targeting a range of therapeutic areas. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the scale-up and optimization of API synthesis routes.
• Biochemical Research: Potential use as a tool compound or inhibitor in enzymatic and receptor-binding assays due to its unique heterocyclic structure.
• Custom Synthesis: Basis for the custom manufacturing of specialized derivatives and analogs for client-specific research and development projects.

Basic Information

Item	Details
Product Name	4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carboxylic Acid
CAS No.	1272756-04-3
Molecular Formula	C13H12N2O3
Molecular Weight	244.25 g/mol
Synonyms	5-Carboxy-4-oxospiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]; 4-Oxo-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclobutane]-5-carboxylic acid; Spiro[cyclobutane-1,2'-quinazoline]-4'(3'H)-one-5'-carboxylic acid; 1272756-04-3; AOB 340; UNII-8V6Q5WQ3VJ
EINECS	Contact for details

Quality Control

Every batch of 4-Oxospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-5-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider inert atmosphere packaging to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.