Description

5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is a high-value, spirocyclic organic compound featuring a fused quinazoline and cyclobutane structure with a fluorine substituent. This unique molecular architecture makes it a critical advanced pharmaceutical intermediate for the research and development of novel active ingredients. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers focused on oncology, neurology, and other therapeutic areas requiring complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology and CNS-targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its spirocyclic and fluorinated properties.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study enzyme function and biological pathways.
• Agrochemical Intermediate: Potential use in the development of new-generation pesticides and herbicides requiring fluorinated heterocycles.
• Material Science Research: Investigated as a precursor for specialty polymers or organic electronic materials with specific optoelectronic properties.

Basic Information

Product Name	5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One
CAS No.	1272756-02-1
Molecular Formula	C12H11FN2O
Molecular Weight	218.23 g/mol
Synonyms	5-Fluoro-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclobutan]-4-one; 5-Fluoro-1,2,3,4-tetrahydro-2,1'-cyclobutanospiro[quinazolin]-4-one; 5-Fluoro-1,2,3,4-tetrahydrospiro[quinazoline-2,1'-cyclobutane]-4-one; 5-Fluoro-1,2,3,4-tetrahydro-2,1'-cyclobutano-spiro[quinazolin]-4-one; Spiro[1,2,3,4-tetrahydroquinazoline-2,1'-cyclobutane]-4-one, 5-fluoro-; 1272756-02-1
EINECS	Contact for details

Quality Control

Our 5-Fluorospiro[1,2,3,4-Tetrahydroquinazoline-2,1'-Cyclobutane]-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.