Description

3-(3-Bromo-4-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic diazepinone scaffold. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: The diazaspiro[4.4]nonane core is of significant interest for creating compounds with potential activity in neurological and psychiatric disorders.
• Oncology Research: Employed in the design and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Chemical Biology: Serves as a probe or tool compound for investigating biological mechanisms and protein-ligand interactions.
• Process Chemistry: Used in the scale-up and route development for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-(3-Bromo-4-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One
CAS No.	1272755-98-2
Molecular Formula	C₁₇H₂₀BrFN₂O
Molecular Weight	367.26 g/mol
Synonyms	1,4-Diazaspiro[4.4]nonan-2-one, 3-(3-bromo-4-fluorophenyl)-; 3-(3-Bromo-4-fluorophenyl)-1,4-diazaspiro[4.4]nonan-2-one; 1272755-98-2; 3-(3-Bromo-4-fluorophenyl)-1,4-diazaspiro[4.4]nonane-2-one; (3-Bromo-4-fluorophenyl)-1,4-diazaspiro[4.4]nonan-2-one; Spiro[diazepine] intermediate; Bromo-fluorophenyl diazaspiro nonanone
EINECS	Contact for details

Quality Control

Our 3-(3-Bromo-4-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.