Description

7-(2-Bromophenyl)-5,8-Diazaspiro[3.4]Octan-6-One is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic diazaoctanone scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those requiring a constrained spirocyclic amine moiety.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs for discovering new therapeutics.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Incorporated into molecular frameworks designed to modulate kinase activity for oncology and inflammatory disease applications.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to partners for the cGMP or non-GMP production of bespoke molecules for preclinical and clinical trials.

Basic Information

Product Name	7-(2-Bromophenyl)-5,8-Diazaspiro[3.4]Octan-6-One
CAS No.	1272755-95-9
Molecular Formula	C13H13BrN2O
Molecular Weight	293.16 g/mol
Synonyms	7-(2-Bromophenyl)-5,8-diazaspiro[3.4]octan-6-one; 5,8-Diazaspiro[3.4]octan-6-one, 7-(2-bromophenyl)-; 1272755-95-9; 7-(2-Bromophenyl)-5,8-diaza-spiro[3.4]octan-6-one; Spiro[3.4]octane-6-one, 7-(2-bromophenyl)-5,8-diaza-; AKOS026710893; AS-76379; ZINC000000049949
EINECS	Contact for details

Quality Control

Our 7-(2-Bromophenyl)-5,8-Diazaspiro[3.4]Octan-6-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment. We support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.