Description

3-(4-Bromo-2-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic scaffold and halogenated aryl group.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and pharmacology studies.

Basic Information

Product Name	3-(4-Bromo-2-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One
CAS No.	1272755-90-4
Molecular Formula	C₁₃H₁₄BrFN₂O
Molecular Weight	313.17 g/mol
Synonyms	3-(4-Bromo-2-fluorophenyl)-1,4-diazaspiro[4.4]nonan-2-one; 1,4-Diazaspiro[4.4]nonan-2-one, 3-(4-bromo-2-fluorophenyl)-; UNII-9V8Q4C2W8F; 9V8Q4C2W8F; 3-(4-Bromo-2-fluorophenyl)-1,4-diazaspiro[4.4]nonane-2-one; 1272755-90-4; AKOS040759626; BDBM50388805.
EINECS	Contact for details

Quality Control

Our 3-(4-Bromo-2-Fluorophenyl)-1,4-Diazaspiro[4.4]Nonan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with client specifications and current industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.