Description

7-[4-(Methylsulfonyl)Phenyl]-5,8-Diazaspiro[3.4]Octan-6-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic and sulfonyl pharmacophores.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Kinase Inhibitor Synthesis: Employed in the development of selective kinase inhibitors, leveraging its diazaspiro[3.4]octane core.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up under cGMP conditions.

Basic Information

Product Name	7-[4-(Methylsulfonyl)Phenyl]-5,8-Diazaspiro[3.4]Octan-6-One
CAS No.	1272755-84-6
Molecular Formula	C13H15N2O3S
Molecular Weight	279.34 g/mol
Synonyms	5,8-Diazaspiro[3.4]octan-6-one, 7-[4-(methylsulfonyl)phenyl]-; 7-(4-Methanesulfonylphenyl)-5,8-diazaspiro[3.4]octan-6-one; 1272755-84-6; Diazaspirooctanone sulfonyl derivative; Spirocyclic sulfonamide intermediate; 7-(4-Methylsulfonylphenyl)-5,8-diazaspiro[3.4]octan-6-one; 5,8-Diazaspiro[3.4]octane-6-one, 7-[4-(methylsulfonyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 7-[4-(Methylsulfonyl)Phenyl]-5,8-Diazaspiro[3.4]Octan-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports development from research to commercial scale under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.