Description

(R)-Methyl 3-Amino-2,3-Dihydrobenzofuran-5-Carboxylate is a high-value, chiral benzofuran derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in its role as a key building block for the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel therapeutics, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the construction of novel herbicides, fungicides, and insecticides that require a chiral benzofuran scaffold for optimal biological activity.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in the development of new chiral catalysts and methodologies.
• Material Science Precursor: Potential building block for the synthesis of organic electronic materials or advanced polymers with specific optical properties.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory synthetic chemistry and method development projects.

Basic Information

Product Name	(R)-Methyl 3-Amino-2,3-Dihydrobenzofuran-5-Carboxylate
CAS No.	1272750-00-1
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	Methyl (3R)-3-amino-2,3-dihydro-1-benzofuran-5-carboxylate; (R)-3-Amino-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester; (R)-Methyl 3-amino-2,3-dihydrobenzofuran-5-carboxylate; 5-Benzofurancarboxylic acid, 3-amino-2,3-dihydro-, methyl ester, (3R)-; (R)-3-Aminodihydrobenzofuran-5-carboxylic acid methyl ester; (R)-Aminodihydrobenzofurancarboxylate
EINECS	Contact for details

Quality Control

We supply (R)-Methyl 3-Amino-2,3-Dihydrobenzofuran-5-Carboxylate with a standard purity of ≥97% (by HPLC), with higher grades (≥98%, ≥99%) available upon request. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity, and residual solvent content. Our quality management system ensures traceability and consistency, meeting the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for critical applications to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% e.e.
Loss on Drying	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.