Description

2-(tert-Butyl) 7-Ethyl 2,6-Diazaspiro[3.4]Octane-2,7-Dicarboxylate is a high-value, advanced pharmaceutical intermediate featuring a constrained spirocyclic diamine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with improved metabolic stability and target selectivity. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing innovative small-molecule therapeutics, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic diamine structure is valuable for constructing linkers and warhead connectors in bifunctional degrader molecules.
• Kinase Inhibitor Synthesis: Employed in the creation of selective kinase inhibitors for targeted cancer therapies.
• CNS Drug Discovery: The scaffold's properties are advantageous for designing compounds intended to cross the blood-brain barrier.
• Chemical Biology Probes: Used to develop tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: Available for custom manufacturing projects from gram to kilogram scale for preclinical and clinical development.

Basic Information

Item	Detail
Product Name	2-(tert-Butyl) 7-Ethyl 2,6-Diazaspiro[3.4]Octane-2,7-Dicarboxylate
CAS No.	1272656-39-9
Molecular Formula	C15H26N2O4
Molecular Weight	298.38 g/mol
Synonyms	tert-Butyl 7-ethyl 2,6-diazaspiro[3.4]octane-2,7-dicarboxylate; 2,6-Diazaspiro[3.4]octane-2,7-dicarboxylic acid, 2-(1,1-dimethylethyl) 7-ethyl ester; 2-(tert-Butoxycarbonyl)-7-ethoxycarbonyl-2,6-diazaspiro[3.4]octane; 2-Boc-7-EtOOC-2,6-diazaspiro[3.4]octane; 2,6-Diazaspiro[3.4]octane-2,7-dicarboxylate, 2-(tert-butyl) 7-ethyl ester; Spirocyclic Diamine Ester; 2,6-Diazaspiro[3.4]octane Boc/Et Diester
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyl) 7-Ethyl 2,6-Diazaspiro[3.4]Octane-2,7-Dicarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.