Description

Azido-Peg2-T-Butyl Ester is a specialized bifunctional PEG linker featuring an azide group and a protected carboxylic acid terminus. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise and efficient coupling of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors developing targeted drug delivery systems, diagnostic reagents, and functionalized hydrogels.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to link peptides, proteins, or oligonucleotides to various carriers.
• ADC (Antibody-Drug Conjugate) Development: Used as a functionalized linker to attach cytotoxic payloads to monoclonal antibodies, creating targeted cancer therapeutics.
• Polymer and Surface Functionalization: Enables the introduction of azide groups onto polymer backbones or material surfaces for subsequent modification with alkyne-bearing molecules.
• Proteomics and Biomolecule Labeling: Facilitates the site-specific labeling of proteins and other biomolecules with fluorescent dyes, affinity tags, or other probes.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker for creating stable covalent bonds between different molecules or materials.
• Nanoparticle and Liposome Modification: Employed to functionalize the surface of nanoparticles or liposomes for targeted delivery applications.
• Solid-Phase Peptide Synthesis (SPPS): Used as a building block to incorporate PEG and azide functionalities into synthetic peptides.
• Materials Science Research: Applied in the synthesis of novel functional materials, such as smart gels and responsive polymers.

Basic Information

Item	Details
Product Name	Azido-Peg2-T-Butyl Ester
CAS No.	1271728-79-0
Molecular Formula	C13H25N3O5
Molecular Weight	303.36 g/mol
Synonyms	1-Azido-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; 15-Azido-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; tert-Butyl 15-azido-4,7,10,13-tetraoxapentadecanoate; Azido-PEG2-t-butyl ester; N3-PEG2-COOtBu; Azido-PEG2-acid t-butyl ester; Azido-PEG2-tBu ester; PEG2 azide t-butyl ester
EINECS	Contact for details

Quality Control

Our Azido-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.