Description

Methyl 4-(1-Amino-2,2,2-Trifluoroethyl)Benzoate CAS NO 1270353-91-7 is a high-value trifluoromethylated aromatic building block, distinguished by its unique combination of an amino group and a benzoate ester. This compound is critical for introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecular architectures, significantly enhancing the biological activity and physicochemical properties of target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, including protease inhibitors, kinase modulators, and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing compounds used in electronic displays and organic light-emitting diodes due to its impact on electronic properties.
• Peptidomimetics & Bioisosteres: The 1-amino-2,2,2-trifluoroethyl moiety is a valuable bioisostere for natural amino acids in medicinal chemistry, aiding in drug optimization.
• Advanced Material Research: Employed in the synthesis of specialty polymers and coatings that require specific fluorine-related characteristics like chemical resistance or low surface energy.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Methyl 4-(1-Amino-2,2,2-Trifluoroethyl)Benzoate
CAS No.	1270353-91-7
Molecular Formula	C10H10F3NO2
Molecular Weight	233.19 g/mol
Synonyms	Benzoic acid, 4-(1-amino-2,2,2-trifluoroethyl)-, methyl ester; Methyl 4-(1-Amino-2,2,2-trifluoroethyl)benzoate; 4-(1-Amino-2,2,2-trifluoroethyl)benzoic acid methyl ester; Methyl p-(1-amino-2,2,2-trifluoroethyl)benzoate; 1270353-91-7; Methyl 4-(1-Amino-2,2,2-trifluoroethyl)benzoate HCl salt (if applicable); α-Amino-α-(trifluoromethyl)-4-(methoxycarbonyl)benzene
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(1-Amino-2,2,2-Trifluoroethyl)Benzoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are manufactured and tested in facilities operating under cGMP principles. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation (IR, NMR), and levels of specific impurities. We support customer audits and can tailor specifications to meet the requirements of your regulatory filings (e.g., FDA, EMA).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.