Description

(S)-1-(4-Chloropyridin-2-Yl)But-3-En-1-Amine is a high-purity chiral amine building block featuring a chloropyridine moiety and a terminal alkene group. This compound is of significant value in medicinal chemistry and pharmaceutical research, serving as a versatile intermediate for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with specific stereochemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Agrochemical Synthesis: Used in the creation of advanced, targeted pesticides and herbicides requiring specific stereoisomers for optimal activity.
• Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study biological pathways and protein function.
• Peptidomimetic Research: Incorporated into peptide analogs to enhance metabolic stability and binding affinity.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	(S)-1-(4-Chloropyridin-2-Yl)But-3-En-1-Amine
CAS No.	1270210-49-5
Molecular Formula	C9H11ClN2
Molecular Weight	182.65 g/mol
Synonyms	(S)-1-(4-Chloro-2-pyridinyl)-3-buten-1-amine; (S)-1-(4-Chloropyridin-2-yl)but-3-en-1-amine; (S)-4-Chloro-2-(1-amino-3-buten-1-yl)pyridine; (S)-1-(4-Chloro-2-pyridyl)-3-butenylamine; (S)-1-(4-Chloro-pyridin-2-yl)-but-3-enylamine; But-3-en-1-amine, 1-(4-chloro-2-pyridinyl)-, (S)-; 1270210-49-5
EINECS	Contact for details

Quality Control

Our (S)-1-(4-Chloropyridin-2-Yl)But-3-En-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR/LC-MS for identity confirmation, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.