Description

5-Chloro-4-(5-Fluoro-2-Methoxy-Phenyl)-Pyridin-2-Ylamine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyridine and substituted phenyl structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly in kinase inhibitor research.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural unit in the development of proprietary APIs for targeted therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for global clients.
• Biochemical Reagent: Employed in biochemical assays to study enzyme interactions and cellular pathways.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in regulatory submissions.

Basic Information

Product Name	5-Chloro-4-(5-Fluoro-2-Methoxy-Phenyl)-Pyridin-2-Ylamine
CAS No.	1269815-38-4
Molecular Formula	C12H10ClFN2O
Molecular Weight	252.67 g/mol
Synonyms	2-Amino-5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridine; 5-Chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-amine; 1269815-38-4; 4-(5-Fluoro-2-methoxyphenyl)-5-chloropyridin-2-amine; 5-Chloro-4-(5-fluoro-2-methoxyphenyl)-2-pyridinamine; AKOS006361991; BDBM50389359; FT-0773297; NS00074567; SCHEMBL21806427
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-(5-Fluoro-2-Methoxy-Phenyl)-Pyridin-2-Ylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.