Description

3-Fluoro-4-Iodopyridin-2-Amine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on an aminopyridine core, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients, as well as by material scientists exploring new functional organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics where the halogenated pyridine scaffold is crucial for bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen atoms for effective binding to biological targets and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands in transition metal catalysis, enabling novel cross-coupling and other catalytic reactions.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and photoactive materials due to the electron-withdrawing nature of the halogens and the potential for further functionalization.
• Chemical Biology Probe Synthesis: Utilized as a scaffold for developing molecular probes and tags for studying biological processes, where the iodine atom allows for further modifications via metal-catalyzed reactions.

Basic Information

Product Name	3-Fluoro-4-Iodopyridin-2-Amine
CAS No.	1269440-67-6
Molecular Formula	C5H4FIN2
Molecular Weight	237.99 g/mol
Synonyms	2-Amino-3-fluoro-4-iodopyridine; 4-Iodo-3-fluoropyridin-2-amine; 3-Fluoro-4-iodo-2-pyridinamine; 3-Fluoro-4-iodo-2-aminopyridine; 2-Pyridinamine, 3-fluoro-4-iodo-; 1269440-67-6; 3-Fluoro-4-iodopyridine-2-amine
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Iodopyridin-2-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.