Description

5-Pyridinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Ethyl Ester is a high-value trifluoromethylated pyridine derivative that serves as a critical building block in advanced organic synthesis. This compound is prized for its unique molecular architecture, which combines a pyridine core with both hydroxyl and trifluoromethyl substituents, enabling precise modulation of electronic and steric properties in target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and enzyme inhibitors.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis.
• Material Science: Employed in the research of advanced organic electronic materials and liquid crystals due to its fluorinated aromatic structure.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes for studying biological processes and protein-ligand interactions.

Basic Information

Product Name	5-Pyridinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1269292-28-5
Molecular Formula	C9H8F3NO3
Molecular Weight	235.16 g/mol
Synonyms	Ethyl 4-hydroxy-2-(trifluoromethyl)nicotinate; 4-Hydroxy-2-(trifluoromethyl)nicotinic acid ethyl ester; 2-(Trifluoromethyl)-4-hydroxynicotinic acid ethyl ester; Ethyl 4-hydroxy-2-(trifluoromethyl)pyridine-5-carboxylate; 5-Carboethoxy-4-hydroxy-2-(trifluoromethyl)pyridine; 4-Hydroxy-2-trifluoromethyl-pyridine-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of 5-Pyridinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Ethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.