Description

2-Amino-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and triaza core structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new drug candidates, especially in areas targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) with potential neurological activity.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for new drug discovery programs.
• Protease Inhibitor Development: The spirocyclic triaza scaffold is valuable for creating inhibitors targeting specific enzymes.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study biological pathways and target validation.
• Preclinical Candidate Synthesis: Employed in the multi-step synthesis of compounds for advanced preclinical evaluation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	2-Amino-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Dihydrochloride
CAS No.	1269106-47-9
Molecular Formula	C9H16Cl2N4O
Molecular Weight	267.16 g/mol
Synonyms	2-Amino-1,3,8-triazaspiro[4.5]dec-1-en-4-one hydrochloride (1:2); 1,3,8-Triazaspiro[4.5]dec-1-en-4-one, 2-amino-, dihydrochloride; Spiro[4.5]decane-2-amino-1,3,8-triaza-4-one dihydrochloride; CAS 1269106-47-9; 2-Amino-1,3,8-triazaspiro[4.5]dec-1-en-4-one HCl; 2-Amino-1,3,8-triazaspiro[4.5]dec-1-en-4-one dihydrochloride salt
EINECS	Contact for details

Quality Control

Our 2-Amino-1,3,8-Triazaspiro[4.5]Dec-1-En-4-One Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.