Description

tert-Butyl 4-(2-Hydroxyphenyl)-3,6-Dihydro-2H-Pyridine-1-Carboxylate is a high-purity, protected piperidine derivative featuring a phenolic hydroxyl group, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its role as a versatile building block for constructing complex nitrogen-containing heterocycles, which are core scaffolds in modern pharmaceuticals. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel active ingredients for therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and oncology.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Development: The phenolic and protected amine functionalities make it a candidate for constructing complex ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and advanced materials requiring specific chiral or functionalized piperidine cores.

Basic Information

Product Name	tert-Butyl 4-(2-Hydroxyphenyl)-3,6-Dihydro-2H-Pyridine-1-Carboxylate
CAS No.	1269025-34-4
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	1-Boc-4-(2-hydroxyphenyl)-1,2,3,6-tetrahydropyridine; tert-Butyl 4-(2-hydroxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylate; 4-(2-Hydroxyphenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; 1,2,3,6-Tetrahydro-4-(2-hydroxyphenyl)pyridine-1-carboxylic acid tert-butyl ester; Boc-4-(2-Hydroxyphenyl)-1,2,3,6-tetrahydropyridine; 1269025-34-4; 4-(2-Hydroxyphenyl)-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Hydroxyphenyl)-3,6-Dihydro-2H-Pyridine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.