Description

tert-Butyl (1-Ethynylcyclopropyl)Carbamate is a specialized organic building block featuring a unique combination of a carbamate protecting group, a reactive ethynyl moiety, and a strained cyclopropane ring. This compound matters as a versatile intermediate for constructing complex molecular architectures in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive alkyne group, enabling click chemistry and other conjugation strategies.
• Agrochemical Research: Serves as a precursor for developing new crop protection agents and pesticides with novel modes of action.
• Material Science: Potential monomer or cross-linker for creating specialty polymers with tailored thermal or mechanical properties.
• Chemical Biology: Useful probe for bioconjugation and labeling of biomolecules via its ethynyl functionality.
• Process Chemistry: Employed in the scalable synthesis of complex targets, where the tert-butyloxycarbonyl (Boc) group provides orthogonal protection for amines.

Basic Information

Product Name	tert-Butyl (1-Ethynylcyclopropyl)Carbamate
CAS No.	1268810-09-8
Molecular Formula	C10H15NO2
Molecular Weight	181.23 g/mol
Synonyms	Boc-1-Ethynylcyclopropylamine; 1-Ethynylcyclopropanamine, N-Boc-protected; tert-Butyl N-(1-ethynylcyclopropyl)carbamate; 1-[(tert-Butoxycarbonyl)amino]cyclopropane-1-carboxylic acid alkyne; (1-Ethynylcyclopropyl)carbamic acid tert-butyl ester; N-Boc-1-ethynylcyclopropanamine; 1-Ethynylcyclopropylcarbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (1-Ethynylcyclopropyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.