Description

8-(Benzyloxycarbonyl)-1-Oxa-8-Azaspiro-[4.6]Undecane-3-Carboxylic Acid CAS NO 1268522-48-0 is a sophisticated spirocyclic building block featuring a protected amine and a carboxylic acid functional group. This compound is of significant value in medicinal chemistry and pharmaceutical research for the synthesis of complex, biologically active molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel drug candidates, particularly those targeting central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new therapeutic areas.
• Protease Inhibitor Synthesis: Serves as a core scaffold in the design and synthesis of protease inhibitors due to its spirocyclic structure.
• Peptidomimetic Development: Employed to create novel peptidomimetics that mimic peptide structures with improved metabolic stability.
• Chemical Biology Probes: Utilized in the creation of specialized probes for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a valuable chiral starting material or auxiliary in stereoselective synthesis campaigns.

Basic Information

Product Name	8-(Benzyloxycarbonyl)-1-Oxa-8-Azaspiro-[4.6]Undecane-3-Carboxylic Acid
CAS No.	1268522-48-0
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	8-(Benzyloxycarbonyl)-1-oxa-8-azaspiro[4.6]undecane-3-carboxylic acid; 1-Oxa-8-azaspiro[4.6]undecane-3-carboxylic acid, 8-[(phenylmethoxy)carbonyl]-; Z-1-Oxa-8-azaspiro[4.6]undecane-3-carboxylic acid; Cbz-1-Oxa-8-azaspiro[4.6]undecane-3-carboxylic acid; 8-Cbz-1-oxa-8-azaspiro[4.6]undecane-3-carboxylic acid; (3S)-8-{[(Benzyloxy)carbonyl]}-1-oxa-8-azaspiro[4.6]undecane-3-carboxylic acid (for chiral form); Spirocyclic Cbz-protected amino acid.
EINECS	Contact for details

Quality Control

Our 8-(Benzyloxycarbonyl)-1-Oxa-8-Azaspiro-[4.6]Undecane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (if applicable)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.