Description

tert-Butyl 1-Isopropyl-7-Oxo-1,4,6,7-Tetrahydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 1268521-74-9. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of kinase inhibition. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Preclinical Development: Serves as a critical material for producing batches of active pharmaceutical ingredients (APIs) for toxicology and early-phase studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	tert-Butyl 1-Isopropyl-7-Oxo-1,4,6,7-Tetrahydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate
CAS No.	1268521-74-9
Molecular Formula	C18H29N3O3
Molecular Weight	335.44 g/mol
Synonyms	1,4,6,7-Tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylic acid, 1-(1-methylethyl)-7-oxo-, 1,1-dimethylethyl ester; 1'-Boc-1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]; tert-Butyl 1-isopropyl-7-oxo-4,6-dihydrospiro[indazole-5,4'-piperidine]-1'-carboxylate; 1268521-74-9; BOC-protected spiroindazolepiperidine derivative
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 1-Isopropyl-7-Oxo-1,4,6,7-Tetrahydrospiro[Indazole-5,4'-Piperidine]-1'-Carboxylate adheres to stringent quality systems suitable for pharmaceutical development. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.