Description

cis-1-Cbz-4-Amino-3-Fluoropiperidine is a high-purity, fluorinated piperidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is specifically engineered to introduce both a protected amine and a fluorine atom in a defined stereochemical configuration, enabling precise modulation of molecular properties. It is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where fluorine substitution and specific stereochemistry are required for optimal bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Research: Used in the synthesis of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances lipophilicity and environmental stability.
• Peptidomimetics & PROTACs: Serves as a constrained scaffold to mimic peptide turn structures or as a linker component in Proteolysis Targeting Chimeras (PROTACs).
• Chemical Biology Probes: Incorporation into molecular probes to study enzyme mechanisms or protein-ligand interactions via fluorine NMR (19F NMR).
• Asymmetric Catalysis Ligand Precursor: The chiral, fluorinated piperidine core can be elaborated into novel ligands for asymmetric synthesis.
• Material Science: Potential monomer or additive for specialty polymers where fluorine content imparts unique surface properties.

Basic Information

Product Name	cis-1-Cbz-4-Amino-3-Fluoropiperidine
CAS No.	1268520-82-6
Molecular Formula	C13H17FN2O2
Molecular Weight	252.29 g/mol
Synonyms	(3R,4S)-1-[(Benzyloxy)carbonyl]-4-amino-3-fluoropiperidine; (3S,4R)-1-[(Benzyloxy)carbonyl]-4-amino-3-fluoropiperidine; cis-1-(Carbobenzyloxy)-4-amino-3-fluoropiperidine; cis-1-Cbz-4-Amino-3-fluoropiperidine; 1-Cbz-cis-4-Amino-3-fluoropiperidine; 1-N-CBZ-cis-4-Amino-3-fluoropiperidine; 1-Benzyloxycarbonyl-cis-4-amino-3-fluoropiperidine; Piperidine, 4-amino-3-fluoro-1-[(phenylmethoxy)carbonyl]-, cis-
EINECS	Contact for details

Quality Control

Our cis-1-Cbz-4-Amino-3-Fluoropiperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity verification by NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.