Description

(2S,4S)-4-Fluoro-2-(Methoxymethyl)Piperidine CAS NO 1268520-61-1 is a high-value, chiral piperidine derivative characterized by its stereochemically defined fluorine and methoxymethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic organic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active ingredients, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis due to its defined stereochemistry and fluorine atom.
• Agrochemical Development: Serves as a building block for creating novel pesticides and herbicides with enhanced activity and selectivity.
• Ligand and Catalyst Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-up: An important intermediate for the pilot and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(2S,4S)-4-Fluoro-2-(Methoxymethyl)Piperidine
CAS No.	1268520-61-1
Molecular Formula	C7H14FNO
Molecular Weight	147.19 g/mol
Synonyms	(2S,4S)-4-Fluoro-2-(methoxymethyl)piperidine; 4-Fluoro-2-(methoxymethyl)piperidine, (2S,4S)-; (2S,4S)-4-Fluoro-2-methoxymethylpiperidine; 4-Fluoro-2-methoxymethylpiperidine (2S,4S)-; 1268520-61-1; (2S,4S)-4-Fluoro-2-(methoxyméthyl)piperidine; (2S,4S)-4-Fluoro-2-(methoxymethyl)piperidin; (2S,4S)-4-Fluoro-2-(methoxymethyl)piperidine HCl salt (if applicable)
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Fluoro-2-(Methoxymethyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development with material produced under GMP-like conditions for non-clinical and clinical stage applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.