Description

5-Aza-Spiro[2.4]Heptane-5,7-Dicarboxylic Acid 5-tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead design for targeted protein degradation platforms.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Advanced Organic Synthesis: Employed in academic and industrial R&D for constructing complex, constrained spirocyclic and heterocyclic systems.
• Process Chemistry: Investigated for scalable routes in the commercial production of high-value fine chemicals.

Basic Information

Product Name	5-Aza-Spiro[2.4]Heptane-5,7-Dicarboxylic Acid 5-tert-Butyl Ester
CAS No.	1268519-54-5
Molecular Formula	C12H17NO4
Molecular Weight	239.27 g/mol
Synonyms	5-(tert-Butyl) 7H-5-azaspiro[2.4]heptane-5,7-dicarboxylate; 5-tert-Butyl 5,7-diazaspiro[2.4]heptane-5,7-dicarboxylate; 5-Azaspiro[2.4]heptane-5,7-dicarboxylic acid, 5-(1,1-dimethylethyl) ester; 5-tert-Butyl 5-azaspiro[2.4]heptane-5,7-dicarboxylate; 5-tert-Butoxycarbonyl-5-azaspiro[2.4]heptane-7-carboxylic acid; CAS 1268519-54-5; tert-Butyl 5,7-diazaspiro[2.4]heptane-5-carboxylate-7-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Aza-Spiro[2.4]Heptane-5,7-Dicarboxylic Acid 5-tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.