Description

(2-(Difluoromethoxy)Pyridin-4-Yl)Methanol is a high-value fluorinated pyridine derivative, a crucial building block in modern synthetic chemistry. Its unique structure, featuring a difluoromethoxy substituent, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or organic semiconductors, where fluorination tunes electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences industry.

Basic Information

Product Name	(2-(Difluoromethoxy)Pyridin-4-Yl)Methanol
CAS No.	1268516-11-5
Molecular Formula	C7H7F2NO2
Molecular Weight	175.13 g/mol
Synonyms	4-(Hydroxymethyl)-2-(difluoromethoxy)pyridine; 2-(Difluoromethoxy)-4-pyridinemethanol; (2-(Difluoromethoxy)-4-pyridinyl)methanol; 4-Pyridinemethanol, 2-(difluoromethoxy)-; 2-Difluoromethoxypyridin-4-ylmethanol
EINECS	Contact for details

Quality Control

Our (2-(Difluoromethoxy)Pyridin-4-Yl)Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profiles, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.