Description

1-Difluoromethyl-Cyclopropanecarboxylic Acid Ethyl Ester CAS NO 1267856-62-1 is a high-value fluorinated cyclopropane derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both a cyclopropane ring and a difluoromethyl group, makes it an essential intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorinated cyclopropane moiety can improve activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials requiring specific fluorinated components for unique surface properties.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for asymmetric catalysis and organometallic chemistry.
• Fluorine Chemistry Building Block: A fundamental reagent for introducing the difluoromethylcyclopropyl group into diverse molecular architectures in academic and industrial R&D.

Basic Information

Product Name	1-Difluoromethyl-Cyclopropanecarboxylic Acid Ethyl Ester
CAS No.	1267856-62-1
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	Ethyl 1-(Difluoromethyl)cyclopropanecarboxylate; 1-(Difluoromethyl)cyclopropanecarboxylic Acid Ethyl Ester; Ethyl 1-Difluoromethylcyclopropanecarboxylate; Cyclopropanecarboxylic acid, 1-(difluoromethyl)-, ethyl ester; Difluoromethylcyclopropanecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of 1-Difluoromethyl-Cyclopropanecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.