Description

Ethyl 3-Cyclopropyl-2,2-Difluoropropanoate is a high-value fluorinated ester building block, essential for introducing the cyclopropyl and difluoromethylenyl motifs into advanced molecular architectures. Its unique structure makes it a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals, where these functional groups are prized for modulating lipophilicity, metabolic stability, and biological activity. This compound is primarily targeted at R&D and process development teams within the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop next-generation compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, antivirals, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the cyclopropyl and fluorine groups enhance efficacy and environmental profile.
• Fluorine Chemistry Research: Serves as a versatile building block in academic and industrial laboratories exploring new fluorination methodologies and the synthesis of complex fluoroorganic molecules.
• Liquid Crystal & Electronic Materials: Potential precursor for the synthesis of fluorinated components used in liquid crystal displays (LCDs) and organic semiconductors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	Ethyl 3-Cyclopropyl-2,2-Difluoropropanoate
CAS No.	1267593-90-7
Molecular Formula	C8H12F2O2
Molecular Weight	178.18 g/mol
Synonyms	Ethyl 3-cyclopropyl-2,2-difluoropropionate; 2,2-Difluoro-3-cyclopropylpropanoic Acid Ethyl Ester; 3-Cyclopropyl-2,2-difluoropropionic Acid Ethyl Ester; Propanoic acid, 3-cyclopropyl-2,2-difluoro-, ethyl ester; Ethyl 3-cyclopropyl-2,2-difluoropropanoate; CAS 1267593-90-7
EINECS	Contact for details

Quality Control

Our Ethyl 3-Cyclopropyl-2,2-Difluoropropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.